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A big comparison of 4 weight loss miracle drugs! Simeglutide vs Tilpotide, with significant differences in differences, side effects, and prices!

Nov 7,2025

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How to Compare Injectable Weight Loss Medications
You may have heard of the trend of many people using injectable drugs to help lose weight and wonder if there are any that are suitable for you.

Achieving and maintaining a healthy weight is not easy, but it brings many health benefits, including reducing the risk of diabetes, heart disease, certain cancers, sleep apnea and other diseases.   

Although diet and exercise alone may achieve the goal, these weight-loss drugs have brought new hope to patients with diabetes or obesity. But you may have many questions:

Are they really effective? How does it work? What is the difference between drugs Mounjaro, Ozempic, Wegovy, and Zepbound? Why choose one of them?   
These drugs have many similarities, but there are also important differences. 

For example, they all belong to a class of drugs called GLP-1 receptor agonists.
Excitants are drugs that mimic the effects of natural substances in the human body. GLP-1 stands for glucagon like peptide-1, which is a hormone secreted by the small intestine. 

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When blood sugar levels rise, GLP-1 prompts the body to secrete more insulin to lower blood sugar, and these drugs also have the same effect.  
How do GLP-1 receptor agonists help with weight loss?   

They may reduce hunger by prolonging the time food stays in the gastrointestinal tract, making it easier to reduce food intake after meals by not feeling hungry for a longer period of time. 

In addition, they also send a "satiety" signal to the brain. Of course, like all medications, these drugs also have drawbacks: they may cause side effects such as nausea, are expensive and may not be covered by medical insurance, require long-term use to maintain weight (unless lifestyle changes are made), and their long-term health effects are not yet clear due to their relatively new nature.  
 
Therefore, if you are considering trying these drugs to lose weight and improve your health, it is best to consult a doctor first. Before deciding to use it, try to gather as much information as possible, ensure that all questions are answered, and make a wise choice that suits you.   

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Which weight loss medication is the best?  
 
Ozempic and Wegovy contain semaglutide, while Mounjaro and Zepbound contain tilpotide. Clinical trials have shown that both can reduce weight, but tilboptin (a dual receptor agonist) has shown a more significant weight loss effect in recent studies (better than semaglutide after 3 months and 1 year), with similar side effects. More research is needed on the long-term effects.   

When making a choice, it is necessary to consider:
Target weight loss range and related health issues (such as hypertension and high cholesterol); Doctor's advice, medical insurance coverage, drug accessibility, and tolerance to side effects.   

Mounjaro, Ozempic, Wegovy, and Zepbound are all relatively new injectable drugs that help reduce food intake by slowing down gastrointestinal peristalsis and sending signals of satiety.

Some drugs are only approved for type 2 diabetes, but all have weight loss effects. Before use, it is necessary to consult a doctor, combine diet and exercise, and weigh the pros and cons.   

Is Zepbound more expensive than Wegovy? The cost varies depending on the medical insurance, and the out of pocket expenses are about $1000 per month. You can apply for a discount plan. (United States)

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Is Zepbound and other injections safe? Overall safe, but there is a risk of side effects. Personal health goals and safety should be discussed with a doctor.   
Can I switch from Ozempic to Zepbound? The mechanisms of the two are similar, but the data on dressing changes is limited. Zepbound may have a better weight loss effect. If Ozempic is out of stock, doctors may recommend replacement and seek professional advice.

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Ozempic vs. Wegovy Ozempic and Wegovy are different brands of the same injectable drug (semaglutide), with differences in indications:
Wegovy is approved to manage the weight of adults and obese children over 12 years old. It is suitable for people who are overweight and have at least one related disease (such as hypertension, type 2 diabetes, high cholesterol).   

Ozempic is approved to reduce blood sugar in patients with type 2 diabetes, and can also be used to reduce the risk of heart attack or stroke in patients with diabetes and heart disease.   

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Dose difference
Wegovy is injected once a week in the abdomen, thighs, or upper arms, gradually increasing from a low dose to 2.4 milligrams.   
Ozempic also starts from a low dose and gradually increases the weekly dose to 0.5 milligrams; If blood sugar control is poor, it may need to be increased to 1 mg/week.   

Common side effects compared to Wegovy include nausea, diarrhea, vomiting, constipation, abdominal pain, indigestion, dizziness, bloating, belching/bloating, hypoglycemia, gastroenteritis, gastroesophageal reflux disease (GERD), headache, fatigue, and nasopharyngitis infection (nasopharyngitis).   

Common side effects of Ozempic include nausea, vomiting, diarrhea, abdominal pain, and constipation.   
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Comparison of weight loss purposes: Wegovy has been approved for weight loss (with low calorie diet and exercise), suitable for people with BMI ≥ 30 (obese); BMI ≥ 27 and accompanied by at least one weight related disease; Children aged 12-18 with a BMI of 95th percentile or higher for their age and gender.   

Ozempic is mainly approved for type 2 diabetes, but as a low-dose version of smeglutide, it is often used to lose weight beyond the instructions. Wegovy has more weight loss data, but due to higher doses, the list of side effects is longer.  

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Other differences
Wegovy has been approved for weight loss (subject to weight or health conditions), while Ozempic has not been approved for weight loss but can be used by doctors beyond the instructions. 

The medical insurance coverage may be different: Ozempic needs to pay for weight loss (unless diagnosed as diabetes), and Wegovy needs to meet weight or health conditions for weight loss. The monthly out of pocket expenses for both are about $1000, which is relatively high. (United States)

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