Currently, there are 7 major challenges in precise fermentation! Amplification process, data-driven, cost efficiency, market acceptance, interdisciplinary ...

The core of precision fermentation technology lies in the use of synthetic biology techniques to modify microorganisms, which requires precise gene editing and cellular metabolic regulation. However, the development of technology is still in its early stages and requires further scientific breakthroughs and technological innovation.

At present, some synthetic biology companies have made significant progress in developing high-performance strains, but at the same time, they have also posed challenges to optimizing and scaling up downstream fermentation processes.

In the process of scaling up from laboratory scale to industrial production, it is necessary to address multi-scale issues in the fermentation process, including fluid dynamics, thermodynamics, and cellular metabolism, which may exhibit different characteristics in reactors of different scales.

Some companies have solved the efficiency and cost issues in traditional batch fermentation processes through their intelligent continuous fermentation technology.

The company's technology aims to increase productivity by 5 to 10 times, significantly improve the efficiency of system operation, reduce the demand for facilities and storage tanks, and thus lower capital and operating costs.

The precise fermentation process generates a large amount of data, and how to effectively utilize this data for process optimization is a challenge. The application of AI technology can optimize fermentation parameters, predict fermentation results, improve fermentation efficiency and product quality. 

For example, AI algorithms can improve the efficiency of fermentation processes by leveraging their big data processing capabilities, model simulation capabilities, and the ability to optimize and guide the fermentation process.

The regulatory environment for precision fermented products is still developing, and clear guidelines are needed to ensure the safety and effectiveness of the products. Meanwhile, the acceptance of new technologies by consumers and industries is also an important factor in promoting precision fermented products.

Although precision fermentation provides the potential for producing high-quality products, its cost-effectiveness and production efficiency remain key considerations for achieving commercialization. Reducing production costs and improving efficiency are important directions for promoting the widespread application of precision fermentation technology.

For example, some companies have achieved the goal of maintaining high microbial yields for a long time through continuous fermentation combined with advanced AI control methods, which has greatly reduced cost expenditures.

Accurate fermentation requires advanced bioreactor and sensor technology to achieve real-time monitoring and control of the process. Developing new sensors and automated control systems is key to achieving precise fermentation process optimization.

For example, new sensors and data acquisition systems can collect real-time data on key parameters during the fermentation process, such as temperature pH、 Dissolved oxygen concentration and other data are crucial for process optimization.

Precision fermentation involves multiple disciplines such as biology, engineering, and information technology, requiring interdisciplinary integration of knowledge and skills to achieve the transformation from basic research to industrial applications.