New favorite of medical aesthetics: hyaluronic acid refined through biological reactions, why does it "debut at the C-position"?
Hyaluronic acid (HA), also known as hyaluronic acid, is a linear polysaccharide formed by alternating connections of N-acetylglucosamine and D-glucuronic acid. It is widely present in human skin, joints, and other tissues, and has excellent moisturizing, repairing, and anti-aging functions.
1、 Medical beauty application scenarios
Small molecule HA (<500kDa): infiltrates into the dermis, promotes collagen regeneration, and is used for deep water supplement such as Shuiguang needle and essence liquid to improve dryness and fine lines. The effect lasts for 4-6 months.
Medium molecular weight HA (500-1500kDa): with a slightly soft texture, it fills soft tissues such as tear troughs and temples, and also has anti-inflammatory effects, lasting 6-12 months.
High molecular weight HA (>1500kDa): forms a physical support network for deep filling such as nose augmentation and buttock augmentation, improving contour stability, and the effect can last for 12-18 months.
2、 Breakthrough in Microbial Fermentation
Strain optimization: For example, the team from Jiangnan University used ARTP mutagenesis technology to modify Streptococcus suis, obtaining a high-yield mutant strain mut-A17. The shaking bottle yield increased by 42.9% to 0.813g/L, and the 5L tank fermentation reached 4.56g/L after 20 hours, significantly shortening the production cycle.
Synthetic biology applications: for example, using CRISPR technology to regulate metabolic pathways, enhance the supply of precursor UDP glucuronic acid, and further increase HA production.
3、 Market situation
In 2023, the market size of HA raw materials in China will reach 4.71 billion yuan, and it is expected to exceed 10 billion yuan by 2025, with a compound annual growth rate of over 20%. The medical beauty field accounts for 47.5%, and injection products contribute 2.5%.
Huaxi Biotechnology has a global market share of over 40%, and its "Runzhi · Tito", as the first compliant kinetic energy product, occupies a technological high ground by intervening in the ECM aging mechanism.
4、 Regulatory and compliance requirements
In China, HA products are divided into drugs (such as ophthalmic gel), the third kind of medical devices (such as injection fillers) and cosmetics (such as moisturizing essence). Injection products need to undergo biocompatibility, sterility testing, and clinical validation.
Overseas, European and American markets require HA raw materials to comply with GMP standards, and medical use must pass FDA or CE certification.
What is GMP equipment? What are the common GMP equipment?
For example, the certification of Class III medical devices by Runbaiyan Bobo marks the entry of domestic HA medical beauty products into a standardized development stage.
Hyaluronic acid, with its multidimensional biological activity and technological innovation, has become a core raw material in the medical beauty and health industry.
In the future, with the improvement of regulations and scientific breakthroughs, HA will further expand its application boundaries and continue to lead anti-aging and regenerative medicine.
