Are bacteria selling at sky high prices? These 8 patented strains support the trillion dollar pharmaceutical market. What does the more expensive "bio chip" look like?
These invisible microorganisms are being empowered through technologies such as CRISPR gene editing, high-density fermentation, and real-time AI regulation, transforming into "bioprinters" capable of "producing everything".
Today, Bailun will take you to learn about some celebrity bacterial strains!
1. Bacillus subtilis
The patented strain produces Bacillus subtilis fibrinolytic enzyme through high-density fermentation, with a thrombolytic activity of 10 million international units/gram and a half-life of over 16 hours, which is more than 40 times that of traditional thrombolytic drugs.
Market value: Oral preparations are used to prevent thrombosis, freeze-dried powder injections have entered the clinical stage, and are expected to be launched in 2030, breaking the monopoly of imported drugs.
2. Sports Fermentation Monomonas
By using CRISPR-Cas9 gene editing to endow self flocculation properties, anaerobic continuous fermentation was achieved to co produce bioethanol (9% v/v) and bioplastic PHB (74% DCW), reducing production costs by 40%.
3. Escherichia coli/yeast (Novo Nordisk)
The expression level of codon optimized strains has increased threefold, with a disulfide bond accuracy rate of over 98%, supporting the annual production capacity of semaglutide to exceed 500 tons.
Market value: 70% of global peptide drugs (such as insulin and octreotide) rely on this technology, and the market size will exceed 200 billion US dollars by 2025.
4. Lactobacillus plantarum P-8
Acid and bile salt resistance, regulating intestinal microbiota, clinically validated to reduce serum cholesterol by 12%, has been used in industrial production of fermented dairy products.
The relevant units have the world's largest collection of lactic acid bacteria germplasm resources (47573 strains), and have constructed the iLABdb database to achieve precise screening of strains.
5. Bifidobacterium brevis CCFM683
The conversion rate of conjugated linoleic acid reaches 90%, regulating intestinal immunity. The probiotic product IberoBiotics, developed in cooperation with Bayer, has entered the ASEAN market.
Market value: Listed in Singapore in 2024, 5 clinical trials have confirmed its adjuvant efficacy for skin health (such as psoriasis).
Guidelines for Avoiding Pits in Bioreactors: Incorrect sterilization parameters at 1 ℃ and incorrect selection of stirring blades can result in millions of losses per minute! (including 10 key details)
6. ASTARTE ™ Probiotic mixture (PrecisionBiotics)
Four patented strains, including Lactobacillus crispus LBV88 and Lactobacillus rhamnosus LBV96, have been clinically validated to increase the colonization rate of vaginal lactobacilli by 200% and reduce yeast levels by 50%.
Market value: Assisted treatment for herpes virus infection in pregnant women reduces the incidence of placental dysfunction by 50%.
7. Jejubacter sp. L23
is tolerant to salt (12% NaCl) and high temperature (45 ℃), and non sterile fermentation produces 41 g/L isobutanol, reducing energy consumption by 30%.
Market value: Inulin is used as raw material to produce biofuels and high value-added chemicals.
8. Ganoderma lucidum strain M624
The stability of factory cultivation has been improved by 30%, the polysaccharide extraction rate has been increased by 25%, and it has won the Silver Award for High Value Patents in the Guangdong Hong Kong Macao Greater Bay Area.
Market value: Applied to Lingzhi Emperor Capsules, with annual sales exceeding 1 billion yuan.
